Growth Hormone Factor 1 (GHF1)

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PIT1; POU1F1; POU Domain Class 1,Transcription Factor 1; Pituitary-specific positive transcription factor 1

Growth Hormone Factor 1 (GHF1)
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans .
PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high-affinity DNA binding on genes encoding growth hormone (GH;) and prolactin (PRL). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB) by thyrotropin-releasing hormone (TRH) and cyclic AMP.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Growth Hormone Factor 1 (GHF1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Growth Hormone Factor 1 (GHF1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Growth Hormone Factor 1 (GHF1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Growth Hormone Factor 1 (GHF1)CLIA Kit Customized Service Offer
n/aELISA Kit for Growth Hormone Factor 1 (GHF1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Growth Hormone Factor 1 (GHF1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Growth Hormone Factor 1 (GHF1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Growth Hormone Factor 1 (GHF1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Growth Hormone Factor 1 (GHF1)CLIA Kit Customized Service Offer
n/aELISA Kit for Growth Hormone Factor 1 (GHF1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Growth Hormone Factor 1 (GHF1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Growth Hormone Factor 1 (GHF1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Growth Hormone Factor 1 (GHF1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Growth Hormone Factor 1 (GHF1)CLIA Kit Customized Service Offer
n/aELISA Kit for Growth Hormone Factor 1 (GHF1)ELISA Kit Customized Service Offer
  1. "Cloning of the human cDNA for transcription factor Pit-1."Nucleic Acids Res. 19:6329-6329(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1."Biochim. Biophys. Acta 1129:231-234(1992) [PubMed] [Europe PMC] [Abstract]
  3. "A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene."Gene 155:273-275(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1."Gene 122:387-388(1992) [PubMed] [Europe PMC] [Abstract]
  5. "A 'hot spot' in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates."J. Clin. Endocrinol. Metab. 80:679-684(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency."Biochem. Biophys. Res. Commun. 189:851-855(1992) [PubMed] [Europe PMC] [Abstract]
  7. "A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency."Science 257:1115-1118(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia."Science 257:1118-1121(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning of a human GHF-1/Pit-1 cDNA variant."Nucleic Acids Res. 21:3584-3584(1993) [PubMed] [Europe PMC] [Abstract]
  10. "A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency."J. Clin. Endocrinol. Metab. 81:2790-2796(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene."Horm. Res. 49:98-102(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency."J. Clin. Endocrinol. Metab. 83:2079-2083(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Combined pituitary hormone deficiency caused by compound heterozygosity for two novel mutations in the POU domain of the PIT1/POU1F1 gene."J. Clin. Endocrinol. Metab. 86:1545-1550(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency."J. Clin. Endocrinol. Metab. 90:4762-4770(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Identification and functional analysis of the novel S179R POU1F1 mutation associated with combined pituitary hormone deficiency."J. Clin. Endocrinol. Metab. 91:4981-4987(2006) [PubMed] [Europe PMC] [Abstract]