≡

Rho GDP Dissociation Inhibitor Alpha (ARHGDIa)

[Edit]

GDIA1; RHOGDI; RHOGDI-1

Rho GDP Dissociation Inhibitor Alpha (ARHGDIa)
CCC E329
HGNC 678
MGI 2178103
PubMed 23867502
RGD 1359547
UniProt P52565
Wiki ARHGDIA
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA.
ARHGDIA corresponded to a protein in the keratinocyte 2-dimensional-gel protein database known as IEF (isoelectric focusing) 8118. By 2-dimensional gel electrophoresis, the predicted 204-amino acid protein had a pI of 4.74 and migrated at 29 kD. The amino acid sequences of human and bovine ARHGDIA are 97% identical. Northern blot analysis revealed that ARHGDIA was expressed in all cell lines and tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE329Hu01 Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE329Hu01 Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) WB; IHC; ICC; IP.
MAE329Hu21 Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) WB; IHC; ICC; IP.
Assay Kits SEE329Hu ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) ELISA Kit Customized Service Offer
  1. "Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton."Exp. Cell Res. 209:165-174(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAY-2006) to UniProtKB
  6. , Submitted (DEC-2008) to UniProtKB
  7. "Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins."Biochemistry 32:5711-5717(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."Mol. Cell 23:607-618(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor alpha with the small GTPase Rac."BMC Biochem. 11:48-48(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells."J. Clin. Invest. 120:2829-2841(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1."Nat. Cell Biol. 12:477-483(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm."Structure 5:623-633(1997) [PubMed] [Europe PMC] [Abstract]
  18. "ARHGDIA: a novel gene implicated in nephrotic syndrome."J. Med. Genet. 50:330-338(2013) [PubMed] [Europe PMC] [Abstract]