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Huntingtin Interacting Protein 2 (HIP2)

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HYPG; LIG; UBE2K; Ubiquitin-Conjugating Enzyme E2K; Ubiquitin carrier protein; Ubiquitin-protein ligase

Huntingtin Interacting Protein 2 (HIP2)
CCC E601
HGNC 4914
MGI 1858216
PubMed 18439290
RGD 1311626
UniProt P61086
Wiki HIP2
HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.
The 200-amino acid HIP2 protein sequence was identical to that of bovine ubiquitin-conjugating enzyme E2-25K. Assays of the interaction of HIP2 with huntingtin revealed that HIP2 binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. Western blot analysis detected protein bands of 25, 28, and 45 kD; the 28-kD band appeared to be selective for tissues of the central nervous system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE601Hu01 Recombinant Huntingtin Interacting Protein 2 (HIP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE601Hu01 Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) WB; IHC; ICC; IP.
Assay Kits SEE601Hu ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein 2 (HIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody Customized Service Offer
Assay Kits SEE601Mu ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein 2 (HIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) ELISA Kit Customized Service Offer
  1. "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme."J. Biol. Chem. 271:19385-19394(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis."Arterioscler. Thromb. Vasc. Biol. 20:128-134(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Regulation of macrophage-specific gene expression by degenerated lipoproteins."Electrophoresis 21:338-346(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)."J. Biol. Chem. 281:20749-20760(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]