Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)

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BWCR; p57; BWS; KIP2; WBS; Beckwith-Wiedemann Syndrome; Cyclin-dependent kinase inhibitor p57

Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)
Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate.
CDKN1C is a tumor suppressor human gene on chromosome 11 and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. Thus p57KIP2 causes arrest of the cell cycle in G1 phase.A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome which is characterized by increased risk of tumor formation in childhood.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase Inhibitor 1C (CDKN1C)ELISA Kit Customized Service Offer
  1. "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene."Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms' tumor assay."Cancer Res. 56:1214-1218(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis."Hum. Genet. 97:625-631(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of germline CDKN1C (p57-KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation."J. Med. Genet. 36:518-523(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome."Nat. Genet. 44:788-792(2012) [PubMed] [Europe PMC] [Abstract]