Receptor Interacting Serine Threonine Kinase 1 (RIPK1)

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RIP; Receptor-Interacting Protein; Cell death protein RIP; Serine/threonine-protein kinase RIP

Receptor Interacting Serine Threonine Kinase 1 (RIPK1)
Two cell surface cytokine receptors, FAS and tumor necrosis factor (TNF) receptor, trigger apoptosis by natural ligands or specific agonist antibodies. Both receptors contain a conserved intracellular death domain. Using a yeast 2-hybrid screen with the cytoplasmic domain of FAS as bait, Stanger et al. (1995) isolated partial cDNAs encoding a receptor-interacting protein which they designated RIP. They used the partial cDNAs to isolate mouse cDNAs corresponding to the entire Rip coding region. Hsu et al. (1996) isolated a full-length human RIP cDNA. They reported that the predicted 671-amino acid RIP protein contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region that they called the intermediate domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE640Hu01 Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE640Hu21 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
PAE640Hu01 Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
MAE640Hu22 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
Assay Kits SEE640Hu ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEE640Hu High Sensitive ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE640Ra01 Recombinant Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE640Ra21 Monoclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
PAE640Ra01 Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 1 (RIPK1) WB; IHC; ICC; IP.
Assay Kits SEE640Ra ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex."Immunity 4:387-396(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."Cell 81:513-523(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis."Genes Dev. 13:2514-2526(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."EMBO J. 18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]
  8. "RIP3, a novel apoptosis-inducing kinase."J. Biol. Chem. 274:16871-16875(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation."Mol. Cell. Biol. 19:5759-5767(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis."Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule."Nat. Immunol. 1:489-495(2000) [PubMed] [Europe PMC] [Abstract]
  12. "The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome."J. Biol. Chem. 276:8865-8874(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation."J. Biol. Chem. 277:15985-15991(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."J. Biol. Chem. 277:9505-9511(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  16. "ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation."J. Biol. Chem. 279:16847-16853(2004) [PubMed] [Europe PMC] [Abstract]
  17. "De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling."Nature 430:694-699(2004) [PubMed] [Europe PMC] [Abstract]
  18. "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction."Nat. Immunol. 6:981-988(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO."Mol. Cell 22:245-257(2006) [PubMed] [Europe PMC] [Abstract]
  20. "RIP1, a kinase on the crossroads of a cell's decision to live or die."Cell Death Differ. 14:400-410(2007) [PubMed] [Europe PMC] [Abstract]
  21. "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."J. Biol. Chem. 282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]
  22. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
  23. "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation."Curr. Biol. 18:641-649(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of RIP1 kinase as a specific cellular target of necrostatins."Nat. Chem. Biol. 4:313-321(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1."J. Biol. Chem. 283:16966-16970(2008) [PubMed] [Europe PMC] [Abstract]
  26. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."Cell 137:1112-1123(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."Cell 137:1100-1111(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Response: CARP1 regulates induction of NF-kappaB by TNFalpha."Curr. Biol. 19:R17-R19(2009)
  30. "The role of the kinases RIP1 and RIP3 in TNF-induced necrosis."Sci. Signal. 3:RE4-RE4(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Linear ubiquitination prevents inflammation and regulates immune signalling."Nature 471:591-596(2011) [PubMed] [Europe PMC] [Abstract]
  33. "cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]
  34. "The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."Cell 148:228-243(2012) [PubMed] [Europe PMC] [Abstract]
  35. "Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]
  36. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  37. "Structural basis of RIP1 inhibition by necrostatins."Structure 21:493-499(2013) [PubMed] [Europe PMC] [Abstract]
  38. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]