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Interleukin 22 Receptor (IL22R)

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IL22RA1; CRF2-9; ZcytoR11; Interleukin 22 Receptor,Alpha 1; Cytokine receptor class-II member 9

Interleukin 22 Receptor (IL22R)
CCC E766
HGNC 13700
MGI 2663588
PubMed 10875937
RGD 1559655
UniProt A8K839
Wiki IL22R
IL22R belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within inflitrated multiple sclerosis lesions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE766Hu01 Recombinant Interleukin 22 Receptor (IL22R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE766Hu01 Polyclonal Antibody to Interleukin 22 Receptor (IL22R) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEE766Hu ELISA Kit for Interleukin 22 Receptor (IL22R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE766Mu01 Recombinant Interleukin 22 Receptor (IL22R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE766Mu01 Polyclonal Antibody to Interleukin 22 Receptor (IL22R) WB; IHC; ICC; IP.
LAE766Mu71 Biotin-Linked Polyclonal Antibody to Interleukin 22 Receptor (IL22R) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Interleukin 22 Receptor (IL22R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 22 Receptor (IL22R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE766Ra01 Recombinant Interleukin 22 Receptor (IL22R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE766Ra01 Polyclonal Antibody to Interleukin 22 Receptor (IL22R) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 22 Receptor (IL22R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 22 Receptor (IL22R) ELISA Kit Customized Service Offer
  1. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes."J. Biol. Chem. 276:2725-2732(2001) [PubMed] [Europe PMC] [Abstract]
  6. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
  7. "IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells."Int. Immunol. 14:1351-1356(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2."J. Biol. Chem. 277:7341-7347(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor."Cancer Res. 63:5105-5113(2003) [PubMed] [Europe PMC] [Abstract]
  11. "IL-22 increases the innate immunity of tissues."Immunity 21:241-254(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2."Int. Immunopharmacol. 4:693-708(2004) [PubMed] [Europe PMC] [Abstract]
  13. "IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro."Am. J. Physiol. 292:G1019-G1028(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A role for T cell-derived interleukin 22 in psoriatic skin inflammation."Clin. Exp. Immunol. 150:407-415(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor."Laryngoscope 117:1839-1843(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation."Nat. Med. 13:1173-1175(2007) [PubMed] [Europe PMC] [Abstract]
  17. "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy."Cytokine 41:16-23(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism."FEBS Lett. 582:2985-2992(2008) [PubMed] [Europe PMC] [Abstract]