Annexin A1 (ANXA1)

[Edit]

ANX-A1; ANX1; LPC1; Lipocortin I; Chromobindin-9; Calpactin II; Phospholipase A2 inhibitory protein

Annexin A1 (ANXA1)
Annexin A1 is a human protein encoded by the ANXA1 gene. Annexin I belongs to a family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia. ANXA1 protein expression is specific to hairy cell leukemia. Detection of ANXA1 (by immunocytochemical means) reportedly provides a simple, highly-sensitive and specific assay for the diagnosis of hairy cell leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE787Hu01Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAE787Hu01Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
MAE787Hu22Monoclonal Antibody to Annexin A1 (ANXA1)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAE787Hu71Biotin-Linked Polyclonal Antibody to Annexin A1 (ANXA1)IHC;WB;ELISA
LAE787Hu81FITC-Linked Polyclonal Antibody to Annexin A1 (ANXA1)IHC;ICC;IF;WB
Assay KitsSEE787HuELISA Kit for Annexin A1 (ANXA1)Enzyme-linked immunosorbent assay for Antigen Detection
SCE787HuCLIA Kit for Annexin A1 (ANXA1)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE787Mu01Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
RPE787Mu02Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAE787Mu01Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
LAE787Mu71Biotin-Linked Polyclonal Antibody to Annexin A1 (ANXA1)IHC;WB;ELISA
PAE787Mu02Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEE787MuELISA Kit for Annexin A1 (ANXA1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE787Ra01Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
RPE787Ra02Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAE787Ra01Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
LAE787Ra71Biotin-Linked Polyclonal Antibody to Annexin A1 (ANXA1)IHC;WB;ELISA
MAE787Ra21Monoclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEE787RaELISA Kit for Annexin A1 (ANXA1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE787Rb01Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
RPE787Rb02Recombinant Annexin A1 (ANXA1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAE787Rb51Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
PAE787Rb52Polyclonal Antibody to Annexin A1 (ANXA1)WB, ICC, IHC-P, IHC-F, ELISA
LAE787Rb71Biotin-Linked Polyclonal Antibody to Annexin A1 (ANXA1)IHC;WB;ELISA
Assay KitsSEE787RbELISA Kit for Annexin A1 (ANXA1)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity."Nature 320:77-81(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Correlation of gene and protein structure of rat and human lipocortin I."Biochemistry 30:9015-9021(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli."Eur. J. Biochem. 211:347-355(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C."Biochemistry 27:3682-3690(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization by tandem mass spectrometry of structural modifications in proteins."Science 237:992-998(1987) [PubMed] [Europe PMC] [Abstract]
  7. "A dimeric form of lipocortin-1 in human placenta."Biochem. J. 263:97-103(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of annexin I by TRPM7 channel-kinase."J. Biol. Chem. 279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human annexin I at 2.5-A resolution."Protein Sci. 2:448-458(1993) [PubMed] [Europe PMC] [Abstract]
  15. "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit."J. Biol. Chem. 274:2971-2977(1999) [PubMed] [Europe PMC] [Abstract]