Fucosyltransferase 6 (FUT6)


FT1A; FCT3A; FucT-VI; Alpha-(1,3)-Fucosyltransferase; Galactoside 3-L-Fucosyltransferase

Fucosyltransferase 6 (FUT6)
The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development. Transfection of FUT6 cDNA into mammalian cells conferred alpha-1,3-fucosyltransferase activity to the cells, resulting in cell surface expression of Lewis x and sialyl-Lewis x carbohydrates. Antibodies raised against another epitope of FUT6 localized the enzyme to Weibel-Palade bodies, endothelial storage granules.

Organism species: Homo sapiens (Human)

ProteinsRPF196Hu01Recombinant Fucosyltransferase 6 (FUT6)SDS-PAGE; WB; ELISA; IP
AntibodiesPAF196Hu01Polyclonal Antibody to Fucosyltransferase 6 (FUT6)WB, ICC, IHC-P, IHC-F, ELISA
MAF196Hu21Monoclonal Antibody to Fucosyltransferase 6 (FUT6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF196HuELISA Kit for Fucosyltransferase 6 (FUT6)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand."Biochem. Biophys. Res. Commun. 187:152-157(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes."J. Biol. Chem. 267:24575-24584(1992) [PubMed] [Europe PMC] [Abstract]
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  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)."J. Biol. Chem. 269:12662-12671(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles."Hum. Mutat. 16:473-481(2000) [PubMed] [Europe PMC] [Abstract]