Docking Protein 7 (DOK7)

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C4orf25; Downstream of tyrosine kinase 7

Docking Protein 7 (DOK7)
DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. DOK7 contains a pleckstrin homology (PH) and PTB domain in the N-terminal portion and Src homology 2 (SH2) domain target motifs in the C-terminal region. Cloning of mouse and pufferfish Dok7 cDNA revealed a highly conserved structure.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Docking Protein 7 (DOK7)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Docking Protein 7 (DOK7)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Docking Protein 7 (DOK7)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Docking Protein 7 (DOK7)CLIA Kit Customized Service Offer
n/aELISA Kit for Docking Protein 7 (DOK7)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Docking Protein 7 (DOK7)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Docking Protein 7 (DOK7)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Docking Protein 7 (DOK7)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Docking Protein 7 (DOK7)CLIA Kit Customized Service Offer
n/aELISA Kit for Docking Protein 7 (DOK7)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF377Ra01Recombinant Docking Protein 7 (DOK7)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF377Ra01Polyclonal Antibody to Docking Protein 7 (DOK7)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Docking Protein 7 (DOK7)CLIA Kit Customized Service Offer
n/aELISA Kit for Docking Protein 7 (DOK7)ELISA Kit Customized Service Offer
  1. "The muscle protein Dok-7 is essential for neuromuscular synaptogenesis."Science 312:1802-1805(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization."Mol. Cell 39:100-109(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Dok-7 mutations underlie a neuromuscular junction synaptopathy."Science 313:1975-1978(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Phenotypical spectrum of DOK7 mutations in congenital myasthenic syndromes." Brain 130:1497-1506(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phenotype genotype analysis in 15 patients presenting a congenital myasthenic syndrome due to mutations in DOK7." J. Neurol. 257:754-766(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The spectrum of mutations that underlie the neuromuscular junction synaptopathy in DOK7 congenital myasthenic syndrome."Hum. Mol. Genet. 21:3765-3775(2012) [PubMed] [Europe PMC] [Abstract]