Spondin 2 (SPON2)
[Edit]DIL1; Mindin; M-spondin; Extracellular Matrix Protein; Differentially expressed in cancerous and non-cancerous lung cells 1
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The full-length SPON2 cDNA encodes a 331-amino acid protein with a domain organization similar to those of zebrafish mindin-1/mindin-2 and F-spondin (SPON1): a hydrophobic signal sequence in the N terminus, an FS1 domain, an FS2 domain, and a thrombospondin type I repeat.
The mouse mindin protein, which is 85% identical to the human protein, is a conserved member of a family of secreted extracellular matrix proteins. RNA blot analysis detected expression in a variety of tissues, with abundant expression in lung and lymphoid tissues. Immunoblot blot analysis showed expression of a 42-kD protein under reducing conditions and expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF396Hu01 | Recombinant Spondin 2 (SPON2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAF396Hu01 | Polyclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. |
| MAF396Hu21 | Monoclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF396Hu | ELISA Kit for Spondin 2 (SPON2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF396Mu01 | Recombinant Spondin 2 (SPON2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPF396Mu02 | Recombinant Spondin 2 (SPON2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAF396Mu01 | Polyclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. |
| PAF396Mu02 | Polyclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF396Mu | ELISA Kit for Spondin 2 (SPON2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF396Ra01 | Recombinant Spondin 2 (SPON2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAF396Ra01 | Polyclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. |
| MAF396Ra21 | Monoclonal Antibody to Spondin 2 (SPON2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF396Ra | ELISA Kit for Spondin 2 (SPON2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display."Genomics 61:5-14(1999) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule."EMBO J. 28:286-297(2009) [PubMed] [Europe PMC] [Abstract]