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Folate Receptor 1, Adult (FOLR1)

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FBP; FOLR; FR-alpha; MOv18; Adult folate-binding protein; KB cells FBP; Ovarian tumor-associated antigen MOv18

Folate Receptor 1, Adult (FOLR1)
CCC F460
HGNC 3791
MGI 95568
PubMed 1717147
RGD 71032
UniProt P15328
Wiki FOLR1
Folate receptor alpha is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF460Hu01 Recombinant Folate Receptor 1, Adult (FOLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF460Hu01 Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB,IHC
MAF460Hu21 Monoclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB
LAF460Hu71 Biotin-Linked Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB; IHC; ICC.
Assay Kits SEF460Hu ELISA Kit for Folate Receptor 1, Adult (FOLR1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCF460Hu CLIA Kit for Folate Receptor 1, Adult (FOLR1) Chemiluminescent immunoassay for Antigen Detection.
AEF460Hu ELISA Kit for Anti-Folate Receptor 1, Adult Antibody (Anti-FOLR1) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF460Mu01 Recombinant Folate Receptor 1, Adult (FOLR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF460Mu02 Recombinant Folate Receptor 1, Adult (FOLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF460Mu01 Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB; IHC; ICC; IP.
PAF460Mu02 Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB; IHC; ICC; IP.
Assay Kits SEF460Mu ELISA Kit for Folate Receptor 1, Adult (FOLR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF460Ra01 Recombinant Folate Receptor 1, Adult (FOLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF460Ra01 Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Folate Receptor 1, Adult (FOLR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Folate Receptor 1, Adult (FOLR1) ELISA Kit Customized Service Offer
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  2. "Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol."J. Clin. Invest. 84:715-720(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Folate-binding protein is a marker for ovarian cancer."Cancer Res. 51:5329-5338(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein."Cancer Res. 51:6125-6132(1991) [PubMed] [Europe PMC] [Abstract]
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  6. "The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure."Biochemistry 36:1467-1478(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA."J. Biol. Chem. 264:5806-5811(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation."Proc. Natl. Acad. Sci. U.S.A. 84:6546-6549(1987) [PubMed] [Europe PMC] [Abstract]
  10. "UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor."Cancer Res. 54:3905-3911(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal."Biochemistry 34:14594-14600(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Endocytosis of GPI-linked membrane folate receptor-alpha."J. Cell Biol. 132:35-47(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments."Proteomics 7:1951-1960(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism."Am. J. Hum. Genet. 85:354-363(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for molecular recognition of folic acid by folate receptors."Nature 500:486-489(2013) [PubMed] [Europe PMC] [Abstract]
  19. "Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition."Proc. Natl. Acad. Sci. U.S.A. 110:15180-15188(2013) [PubMed] [Europe PMC] [Abstract]