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2',5'-Oligoadenylate Synthetase Like Protein (OASL)

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TRIP14; p59OASL; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14

2',5'-Oligoadenylate Synthetase Like Protein (OASL)
CCC F691
HGNC 8090
MGI 2180849
PubMed 19203244
RGD 1308586
UniProt Q15646
Wiki OASL
The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. In a screen for TR-interacting proteins (TRIPs),
The predicted 514-amino acid p59OASL shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. Northern blot analysis revealed that p59OASL is expressed in most tissues, with the highest levels in primary blood leukocytes and other hematopoietic system tissues, colon, and stomach. p59OASL transcription is induced by interferon. The p59OASL gene contains 6 exons. Exons 1-5 are similar in structure to exons 3-7 of OAS1, suggesting that the 2 genes arose from a duplication of an ancestral gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF691Hu01 Recombinant 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF691Hu21 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) WB; IHC; ICC; IP.
PAF691Hu01 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) WB; IHC; ICC; IP.
Assay Kits SEF691Hu ELISA Kit for 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 2',5'-Oligoadenylate Synthetase Like Protein (OASL) CLIA Kit Customized Service Offer
n/a ELISA Kit for 2',5'-Oligoadenylate Synthetase Like Protein (OASL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase Like Protein (OASL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 2',5'-Oligoadenylate Synthetase Like Protein (OASL) CLIA Kit Customized Service Offer
n/a ELISA Kit for 2',5'-Oligoadenylate Synthetase Like Protein (OASL) ELISA Kit Customized Service Offer
  1. "p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family."Nucleic Acids Res. 26:4121-4127(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase."Eur. J. Biochem. 257:319-330(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of OASL d, a splice variant of human OASL, with antiviral activity."Int. J. Biochem. Cell Biol. 44:1133-1138(2012) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1."Eur. J. Biochem. 271:628-636(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."Biochimie 89:779-788(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain."J. Gen. Virol. 89:2767-2772(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Differential regulation of the OASL and OAS1 genes in response to viral infections."J. Interferon Cytokine Res. 29:199-207(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."J. Mol. Evol. 69:612-624(2009) [PubMed] [Europe PMC] [Abstract]
  13. "2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro."Biochem. Biophys. Res. Commun. 392:397-402(2010) [PubMed] [Europe PMC] [Abstract]
  14. "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."J. Interferon Cytokine Res. 31:41-47(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of C-terminal ubiquitin-like domain of human 2'-5'-oligoadenylate synthetase-like protein (p59 OASL)."Submitted (NOV-2004) to the PDB data bank