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Ribonucleotide Reductase M1 (RRM1)

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R1; RIR1; RR1; Ribonucleoside-diphosphate reductase large subunit

Ribonucleotide Reductase M1 (RRM1)
CCC F914
HGNC 10451
MGI 98180
PubMed 23470290
RGD 1598288
UniProt P23921
Wiki RRM1
RRM1 encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF914Hu01 Recombinant Ribonucleotide Reductase M1 (RRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF914Hu01 Polyclonal Antibody to Ribonucleotide Reductase M1 (RRM1) WB; IHC; IF
MAF914Hu21 Monoclonal Antibody to Ribonucleotide Reductase M1 (RRM1) WB; IHC; ICC; IP.
Assay Kits SEF914Hu ELISA Kit for Ribonucleotide Reductase M1 (RRM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF914Mu01 Recombinant Ribonucleotide Reductase M1 (RRM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF914Mu02 Recombinant Ribonucleotide Reductase M1 (RRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF914Mu01 Polyclonal Antibody to Ribonucleotide Reductase M1 (RRM1) WB; IHC; ICC; IP.
PAF914Mu02 Polyclonal Antibody to Ribonucleotide Reductase M1 (RRM1) WB; IHC; ICC; IP.
Assay Kits SEF914Mu ELISA Kit for Ribonucleotide Reductase M1 (RRM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonucleotide Reductase M1 (RRM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonucleotide Reductase M1 (RRM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonucleotide Reductase M1 (RRM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonucleotide Reductase M1 (RRM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonucleotide Reductase M1 (RRM1) ELISA Kit Customized Service Offer
  1. "Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes."Nucleic Acids Res. 19:3741-3741(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence analysis of the large and small subunits of human ribonucleotide reductase."DNA Seq. 2:227-234(1992) [PubMed] [Europe PMC] [Abstract]
  3. "A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region."Genomics 55:164-175(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene."Genomics 19:91-96(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Human ribonucleotide reductase. Activation and inhibition by analogs of ATP."Biochem. Pharmacol. 42:759-763(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits."Cancer Res. 63:980-986(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits."Biochem. Biophys. Res. Commun. 340:428-434(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes."Science 345:1512-1515(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization."Nat. Struct. Mol. Biol. 18:316-322(2011) [PubMed] [Europe PMC] [Abstract]