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Spectrin Beta, Non Erythrocytic 4 (SPTbN4)

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QV; SPNB4; SPTBN3; Beta-IV spectrin; Spectrin, non-erythroid beta chain 3

Spectrin Beta, Non Erythrocytic 4 (SPTbN4)
CCC F950
HGNC 14896
MGI 1890574
PubMed 24030951
RGD 1304682
UniProt Q9H254
Wiki SPTBN4
Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits.
SPTbN4 is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. Abundantly expressed in brain and pancreatic islets.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF950Hu01 Recombinant Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF950Hu21 Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) WB; IHC; ICC; IP.
PAF950Hu01 Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) WB,IHC
Assay Kits SEF950Hu ELISA Kit for Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 4 (SPTbN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 4 (SPTbN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 4 (SPTbN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 4 (SPTbN4) ELISA Kit Customized Service Offer
  1. "A new spectrin, beta-IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix."J. Biol. Chem. 276:23974-23985(2001) [PubMed] [Europe PMC] [Abstract]
  2. "BetaIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system."J. Cell Biol. 151:985-1002(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]