K-Acetyltransferase 2B (KAT2B)


PCAF; P/CAF; GCN5; GCN5L; P300/CBP-Associated Factor; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B

K-Acetyltransferase 2B (KAT2B)
Several domains of PCAF can act independently or in unison to enable its functions. PCAF has separate acetyltransferase and E3 ubiquitin ligase domains as well as a bromodomain for interaction with other proteins. PCAF also possesses sites for its own acetylation and ubiquitination.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by the PCAF gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.

Organism species: Homo sapiens (Human)

Proteins RPG189Hu01 Recombinant K-Acetyltransferase 2B (KAT2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 2B (KAT2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 2B (KAT2B) Polyclonal Antibody Customized Service Offer
Assay Kits SEG189Hu ELISA Kit for K-Acetyltransferase 2B (KAT2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins n/a Recombinant K-Acetyltransferase 2B (KAT2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 2B (KAT2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 2B (KAT2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 2B (KAT2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 2B (KAT2B) ELISA Kit Customized Service Offer
  1. "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A."Nature 382:319-324(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The transcriptional coactivators p300 and CBP are histone acetyltransferases."Cell 87:953-959(1996) [PubMed] [Europe PMC] [Abstract]
  4. "TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1."J. Biol. Chem. 272:27629-27634(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Steroid receptor coactivator-1 is a histone acetyltransferase."Nature 389:194-198(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases."Proc. Natl. Acad. Sci. U.S.A. 95:9855-9860(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of E2F1 activity by acetylation."EMBO J. 19:662-671(2000) [PubMed] [Europe PMC] [Abstract]
  8. "p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex."J. Biol. Chem. 275:11852-11857(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF."EMBO J. 21:6811-6819(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1."J. Biol. Chem. 279:41477-41486(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation."Mol. Cell. Proteomics 5:2072-2082(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF."J. Cell. Biochem. 101:1252-1265(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5."Proc. Natl. Acad. Sci. U.S.A. 104:2703-2708(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation."Mol. Cell 27:609-621(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."Mol. Endocrinol. 21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth."Mol. Cell 51:506-518(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A."EMBO J. 18:3521-3532(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Structure and ligand of a histone acetyltransferase bromodomain."Nature 399:491-496(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain."Mol. Cell 9:575-586(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]