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N-Acetyltransferase 2 (NAT2)

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AAC2; PNAT; Arylamine N-Acetyltransferase; Arylamide acetylase 2; Polymorphic arylamine N-acetyltransferase

N-Acetyltransferase 2 (NAT2)
CCC G192
HGNC 7646
MGI 97279
PubMed 16112301
RGD 70490
UniProt P11245
Wiki NAT2
NAT2 isa type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity.
NAT2 encodes the polymorphic NAT protein because the gene product had an identical apparent molecular weight to that of NAT detected in human liver cytosol and the deduced amino acid sequence of NAT2 contained 6 peptide sequences that had previously been determined from tryptic peptides of the polymorphic NAT purified from human liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 2 (NAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 2 (NAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 2 (NAT2) Polyclonal Antibody Customized Service Offer
Assay Kits SEG192Hu ELISA Kit for N-Acetyltransferase 2 (NAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 2 (NAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 2 (NAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 2 (NAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetyltransferase 2 (NAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetyltransferase 2 (NAT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG192Ra01 Recombinant N-Acetyltransferase 2 (NAT2) Positive Control; Immunogen; SDS-PAGE; WB.
APG192Ra01 Active N-Acetyltransferase 2 (NAT2) Cell culture; Activity Assays.
Antibodies MAG192Ra21 Monoclonal Antibody to N-Acetyltransferase 2 (NAT2) WB; IHC; ICC; IP.
PAG192Ra01 Polyclonal Antibody to N-Acetyltransferase 2 (NAT2) WB
Assay Kits SEG192Ra ELISA Kit for N-Acetyltransferase 2 (NAT2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation."Nucleic Acids Res. 17:3978-3978(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver."J. Biol. Chem. 267:18140-18147(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles."Drug Metab. Dispos. 22:371-376(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes."Am. J. Hum. Genet. 78:423-436(2006) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver."FEBS Lett. 244:203-207(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Diverse point mutations in the human gene for polymorphic N-acetyltransferase."Proc. Natl. Acad. Sci. U.S.A. 88:6333-6337(1991) [PubMed] [Europe PMC] [Abstract]
  13. "The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population."Biochem. Biophys. Res. Commun. 191:811-816(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene."Pharmacogenetics 4:125-134(1994) [PubMed] [Europe PMC] [Abstract]