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Pregnancy Zone Protein (PZP)

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CPAMD6; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

Pregnancy Zone Protein (PZP)
CCC G324
HGNC 9750
MGI 87854
PubMed 1692292
RGD 628643
UniProt P20742
Wiki PZP
Pregnancy zone protein (PZP), one of the major pregnancy-associated plasma proteins, was described by Smithies (1959) who used zone-electrophoresis in starch gels. PZP is a prominent constituent of late-pregnancy sera. In healthy, nonpregnant females and in males, PZP is present in trace amounts only: females, 10-30 mg/l; males, less than 10 mg/l. During pregnancy, PZP levels may reach 1000-1400 mg/l just before term. Sottrup-Jensen et al. (1984) showed that PZP closely resembles alpha-2-macroglobulin in structure. Both have a quaternary structure of 2 covalently bound 180-kD subunits which are further noncovalently assembled into a tetramer of 720 kD. Amino acid sequence of the 2 proteins are extensively homologous.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG324Hu01 Recombinant Pregnancy Zone Protein (PZP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG324Hu01 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
LAG324Hu71 Biotin-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC.
MAG324Hu21 Monoclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
LAG324Hu91 HRP-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC.
Assay Kits SEG324Hu ELISA Kit for Pregnancy Zone Protein (PZP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG324Mu01 Recombinant Pregnancy Zone Protein (PZP) Positive Control; Immunogen; SDS-PAGE; WB.
RPG324Mu02 Recombinant Pregnancy Zone Protein (PZP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG324Mu01 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
LAG324Mu81 FITC-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IF.
LAG324Mu71 Biotin-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC.
PAG324Mu02 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
LAG324Mu72 Biotin-Linked Monoclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC.
PAG324Mu06 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
PAG324Mu03 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
PAG324Mu04 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
PAG324Mu05 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IP.
Assay Kits SEG324Mu ELISA Kit for Pregnancy Zone Protein (PZP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG324Ra01 Recombinant Pregnancy Zone Protein (PZP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG324Ra01 Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC
LAG324Ra81 FITC-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC; IF.
LAG324Ra71 Biotin-Linked Polyclonal Antibody to Pregnancy Zone Protein (PZP) WB; IHC; ICC.
Assay Kits SEG324Ra ELISA Kit for Pregnancy Zone Protein (PZP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction."Biochim. Biophys. Acta 1088:95-103(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Alpha-macroglobulin domain structure studied by specific limited proteolysis."Arch. Biochem. Biophys. 300:327-334(1993) [PubMed] [Europe PMC] [Abstract]
  5. "A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin."FEBS Lett. 262:349-352(1990) [PubMed] [Europe PMC] [Abstract]
  6. "The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins."J. Biol. Chem. 264:15781-15789(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin."J. Biol. Chem. 260:15723-15735(1985) [PubMed] [Europe PMC] [Abstract]
  8. "A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene."Gene 81:325-334(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine."Biochemistry 28:9324-9331(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]