Cerebral Dopamine Neurotrophic Factor (CDNF)
[Edit]ARMETL1; ARMET-like protein 1; Conserved Dopamine Neurotrophic Factor; Arginine-Rich,Mutated In Early Stage Tumors-Like 1
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CDNF shares 59% amino acid identity with human MANF, and 49% and 46% identity with D. melanogaster and C. elegans Manf proteins, respectively. In the midbrain, Cdnf mRNA was expressed from embryonic stages to the adult. High levels of Cdnf mRNA were observed in adult mouse heart, skeletal muscle, and testis. In agreement with the results from mouse, wide expression of CDNF transcripts was detected in human brain and nonneuronal tissues. Interestingly, levels of CDNF transcripts were relatively high in the corpus callosum and optic nerve, which are devoid of neuronal cell bodies and contain mostly axonal projections and oligodendrocytes. At postnatal stage P10 of the mouse brain, Cdnf staining was most intense in the hippocampus and thalamus. Cdnf signal was also detected in striatum and substantia nigra.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG458Hu01 | Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPG458Hu61 | Eukaryotic Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APG458Hu61 | Active Cerebral Dopamine Neurotrophic Factor (CDNF) | Cell culture; Activity Assays. | |
| Antibodies | PAG458Hu01 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. |
| MAG458Hu21 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB,IHC | |
| PAG458Hu06 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| MAG458Hu22 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| MAG458Hu26 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG458Hu | ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG458Mu01 | Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG458Mu02 | Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG458Mu01 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. |
| MAG458Mu22 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| PAG458Mu02 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| MAG458Mu21 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| MAG458Mu23 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG458Ra01 | Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG458Ra02 | Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG458Ra01 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. |
| PAG458Ra02 | Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| LAG458Ra71 | Biotin-Linked Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC. | |
| MAG458Ra21 | Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG458Ra | ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo."Nature 448:73-77(2007) [PubMed] [Europe PMC] [Abstract]
- "Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death."Exp. Cell Res. 314:2454-2467(2008) [PubMed] [Europe PMC] [Abstract]
- "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional."Protein Eng. Des. Sel. 22:233-241(2009) [PubMed] [Europe PMC] [Abstract]