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Lysophosphatidylcholine Acyltransferase 1 (LPCAT1)

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AYTL2; PFAAP3; Acyltransferase Like 2; 1-alkylglycerophosphocholine O-acetyltransferase; Phosphonoformate immuno-associated protein 3; Acetyl-CoA:lyso-PAF acetyltransferase

Lysophosphatidylcholine Acyltransferase 1 (LPCAT1)
CCC G529
HGNC 25718
MGI 2384812
PubMed 21685381
RGD 1311599
UniProt Q8NF37
Wiki LPCAT1
Lysophosphatidylcholine (LPC) acyltransferase (LPCAT) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.
deduced 534-amino acid mouse and human proteins contain 3 transmembrane domains, several motifs conserved in members of the LPCAT family, a putative EF hand domain, and a C-terminal endoplasmic reticulum (ER) retention signal. They share about 88% amino acid identity. Real-time RT-PCR of mouse tissues showed that Lpcat1 was expressed at highest levels in lung, followed by spleen and brain. Other tissues had low Lpcat1 levels. Confocal microscopy detected epitope-tagged Lpcat1 mainly in the ER and Golgi of transfected cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG529Hu01 Recombinant Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG529Hu01 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) WB; IHC; ICC; IP.
MAG529Hu21 Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) WB; IHC; ICC; IP.
Assay Kits SEG529Hu ELISA Kit for Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEG529Hu High Sensitive ELISA Kit for Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG529Mu01 Recombinant Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG529Mu02 Recombinant Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG529Mu01 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) WB; IHC; ICC; IP.
PAG529Mu02 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) WB; IHC; ICC; IP.
Assay Kits SEG529Mu ELISA Kit for Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells."Proc. Natl. Acad. Sci. U.S.A. 103:11724-11729(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine."J. Biol. Chem. 286:21330-21339(2011) [PubMed] [Europe PMC] [Abstract]