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Discs, Large Homolog 3 (DLG3)

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MRX; XLMR; MRX90; NE-Dlg; NEDLG; SAP102; Neuroendocrine-Dlg; Synapse-associated protein 102

Discs, Large Homolog 3 (DLG3)
CCC G764
HGNC 2902
MGI 1888986
PubMed 24381070
RGD 68423
UniProt Q92796
Wiki DLG3
DLG3 is a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
The predicted 817-amino acid protein contains the 3 DHR segments, central SH3 motif, and C-terminal guanylate kinase domain characteristic of MAGUK proteins. NEDLG shares 75% and 60% protein sequence identity with DLG1 and Drosophila dlg, respectively. NEDLG is highly expressed in neuronal and endocrine tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG764Hu01 Recombinant Discs, Large Homolog 3 (DLG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG764Hu21 Monoclonal Antibody to Discs, Large Homolog 3 (DLG3) WB; IHC; ICC; IP.
PAG764Hu01 Polyclonal Antibody to Discs, Large Homolog 3 (DLG3) WB; IHC
Assay Kits SEG764Hu ELISA Kit for Discs, Large Homolog 3 (DLG3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog 3 (DLG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog 3 (DLG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog 3 (DLG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog 3 (DLG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog 3 (DLG3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog 3 (DLG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog 3 (DLG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog 3 (DLG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog 3 (DLG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog 3 (DLG3) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein."Oncogene 14:2425-2433(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Binding of neuroligins to PSD-95."Science 277:1511-1515(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses."Proc. Natl. Acad. Sci. U.S.A. 97:3596-3601(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation." Am. J. Hum. Genet. 75:318-324(2004) [PubMed] [Europe PMC] [Abstract]
  9. "SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses."Neuron 50:233-245(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the third PDZ domain of synapse-associated protein 102."Submitted (MAR-2004) to the PDB data bank
  14. "The crystal structure of the second PDZ domain of human DLG3."Submitted (DEC-2005) to the PDB data bank
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]