Recombination Activating Gene 2 (RAG2)

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Recombination Activating Gene 2 (RAG2)
RAG2 encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Recombination Activating Gene 2 (RAG2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Recombination Activating Gene 2 (RAG2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Recombination Activating Gene 2 (RAG2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Recombination Activating Gene 2 (RAG2)CLIA Kit Customized Service Offer
n/aELISA Kit for Recombination Activating Gene 2 (RAG2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Recombination Activating Gene 2 (RAG2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Recombination Activating Gene 2 (RAG2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Recombination Activating Gene 2 (RAG2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Recombination Activating Gene 2 (RAG2)CLIA Kit Customized Service Offer
n/aELISA Kit for Recombination Activating Gene 2 (RAG2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Recombination Activating Gene 2 (RAG2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Recombination Activating Gene 2 (RAG2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Recombination Activating Gene 2 (RAG2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Recombination Activating Gene 2 (RAG2)CLIA Kit Customized Service Offer
n/aELISA Kit for Recombination Activating Gene 2 (RAG2)ELISA Kit Customized Service Offer
  1. "Sequence and chromosome assignment to 11p13-p12 of human RAG genes."Immunol. Lett. 33:277-284(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression."Blood 78:2053-2061(1991) [PubMed] [Europe PMC] [Abstract]
  5. "RAG mutations in human B cell-negative SCID."Science 274:97-99(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Partial V(D)J recombination activity leads to Omenn syndrome."Cell 93:885-896(1998) [PubMed] [Europe PMC] [Abstract]
  7. "An immunodeficiency disease with RAG mutations and granulomas."N. Engl. J. Med. 358:2030-2038(2008) [PubMed] [Europe PMC] [Abstract]