Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)

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LOT1; ZAC; ZAC1; Zinc finger protein PLAGL1; Lost on transformation 1; Tumor suppressor ZAC

Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)
PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.The deduced 667-amino acid protein contains 7 C2H2 zinc fingers in its N-terminal half. Northern blot analysis of several mouse tissues detected highest Zac1 expression in pituitary.Rat and human LOT1 share 67.7% amino acid identity overall, with 85.5% identity in the N-terminal zinc finger region. Northern blot analysis detected multiple LOT1 transcripts in all human tissues examined, including spleen, thymus, prostate, testis, ovary, intestine, colon, and leukocytes. Highest expression was detected in ovary.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH380Hu01Recombinant Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH380Hu01Polyclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)WB, ICC, IHC-P, IHC-F, ELISA
LAH380Hu71Biotin-Linked Polyclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)IHC;WB;ELISA
MAH380Hu21Monoclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH380HuELISA Kit for Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)CLIA Kit Customized Service Offer
n/aELISA Kit for Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)CLIA Kit Customized Service Offer
n/aELISA Kit for Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)ELISA Kit Customized Service Offer
  1. "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
  3. "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer."Proc. Natl. Acad. Sci. U.S.A. 95:8835-8840(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities."Oncogene 20:1246-1253(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1."Int. J. Biochem. Cell Biol. 40:1826-1834(2008) [PubMed] [Europe PMC] [Abstract]