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Paired Like Homeodomain Transcription Factor 2 (PITX2)

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PTX2; ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; RGS; RIEG; RIEG1; RS; Solurshin; Pituitary homeobox 2; RIEG bicoid-related homeobox transcription factor

Paired Like Homeodomain Transcription Factor 2 (PITX2)
CCC H386
HGNC 9005
MGI 109340
PubMed 23132660
RGD 3331
UniProt Q99697
Wiki PITX2
PITX2 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in this gene are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes. This protein is involved in the development of the eye, tooth and abdominal organs. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 2 (PITX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 2 (PITX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 2 (PITX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 2 (PITX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 2 (PITX2) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome."Nat. Genet. 14:392-399(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene."Proc. Natl. Acad. Sci. U.S.A. 95:4573-4578(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant."Biochemistry 51:665-676(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene."Am. J. Ophthalmol. 125:98-100(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome."Hum. Mol. Genet. 7:1113-1117(1998) [PubMed] [Europe PMC] [Abstract]
  8. "A mutation in the RIEG1 gene associated with Peters' anomaly."J. Med. Genet. 36:152-155(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Phenotypic variability and asymmetry of Rieger syndrome associated with PITX2 mutations."Invest. Ophthalmol. Vis. Sci. 41:2456-2460(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Functional analyses of two newly identified PITX2 mutants reveal a novel molecular mechanism for Axenfeld-Rieger syndrome."Hum. Mol. Genet. 10:1631-1638(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Four novel mutations in the PITX2 gene in patients with Axenfeld-Rieger syndrome."Ophthalmic Res. 34:324-326(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Mutation in PITX2 is associated with ring dermoid of the cornea."J. Med. Genet. 41:E129-E129(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations."Invest. Ophthalmol. Vis. Sci. 47:3846-3852(2006) [PubMed] [Europe PMC] [Abstract]
  14. ErratumInvest. Ophthalmol. Vis. Sci. 47:5162-5162(2006)