3-Oxoacid Coenzyme A Transferase 1 (OXCT1)

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OXCT; SCOT; Succinyl-CoA:3-Ketoacid-Coenzyme A Transferase 1,Mitochondrial; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase

3-Oxoacid Coenzyme A Transferase 1 (OXCT1)
OXCT1encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.OXCT1 is a mitochondrial matrix enzyme that functions as a homodimer. From human heart cDNA libraries, Kassovska-Bratinova et al. (1996) cloned cDNAs spanning the entire 1,560-bp coding sequence using pig heart OXCT1 cDNA as a probe. They reported that a single mRNA transcript of 3.2 kb was present in human tissues. OXCT1 mRNA was most abundant in heart and was also detectable in leukocytes and fibroblasts.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH480Hu01Recombinant 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAH480Hu21Monoclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)WB, ICC, IHC-P, IHC-F, ELISA
PAH480Hu01Polyclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH480HuELISA Kit for 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)CLIA Kit Customized Service Offer
n/aELISA Kit for 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)CLIA Kit Customized Service Offer
n/aELISA Kit for 3-Oxoacid Coenzyme A Transferase 1 (OXCT1)ELISA Kit Customized Service Offer
  1. "Succinyl CoA:3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT-deficient patient."Am. J. Hum. Genet. 59:519-528(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Succinyl-CoA:3-ketoacid CoA transferase (SCOT): cloning of the human SCOT gene, tertiary structural modeling of the human SCOT monomer, and characterization of three pathogenic mutations."Genomics 68:144-151(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (FEB-1997) to UniProtKB
  7. , Submitted (DEC-2008) to UniProtKB
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human 3-oxoacid CoA transferase 1."Submitted (AUG-2008) to the PDB data bank
  12. "Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency: two pathogenic mutations, V133E and C456F, in Japanese siblings."Hum. Mutat. 12:83-88(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Clinical and molecular characterization of five patients with succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency."Biochim. Biophys. Acta 1812:619-624(2011) [PubMed] [Europe PMC] [Abstract]