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N-Acetylgalactosaminidase Alpha (NAGa)

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Alpha-N-Acetylgalactosaminidase; Alpha-galactosidase B

N-Acetylgalactosaminidase Alpha (NAGa)
CCC H574
HGNC 7631
MGI 1261422
PubMed 23394493
RGD 1306025
UniProt P17050
Wiki NAGA
Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) is a lysosomal glycohydrolase that cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates.
The cDNA encodes a 411-amino acid protein with a 17-residue signal peptide and 6 putative N-glycosylation sites. Northern blot analysis detected 2 mRNA transcripts of 3.6 and 2.2 kb. Sequence analysis revealed striking similarities between the NAGA gene and exons 1-6 of the alpha-galactosidase A gene (GLA), suggesting that the 2 genes evolved by duplication and divergence from a common ancestral locus. Wang and Desnick (1991) also pointed to remarkable amino acid identity between the NAGA and GLA genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH574Hu01 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
RPH574Hu02 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH574Hu01 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
PAH574Hu02 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
LAH574Hu71 Biotin-Linked Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC.
Assay Kits SEH574Hu ELISA Kit for N-Acetylgalactosaminidase Alpha (NAGa) Enzyme-linked immunosorbent assay for Antigen Detection.
AEH574Hu ELISA Kit for Anti-N-Acetylgalactosaminidase Alpha Antibody (Anti-NAGa) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH574Mu01 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
RPH574Mu02 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH574Mu01 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
PAH574Mu02 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
LAH574Mu71 Biotin-Linked Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC.
Assay Kits SEH574Mu ELISA Kit for N-Acetylgalactosaminidase Alpha (NAGa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH574Ra01 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
RPH574Ra02 Recombinant N-Acetylgalactosaminidase Alpha (NAGa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH574Ra01 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
PAH574Ra02 Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC; IP.
LAH574Ra71 Biotin-Linked Polyclonal Antibody to N-Acetylgalactosaminidase Alpha (NAGa) WB; IHC; ICC.
Assay Kits SEH574Ra ELISA Kit for N-Acetylgalactosaminidase Alpha (NAGa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene."J. Biol. Chem. 265:21859-21866(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha-galactosidase A gene provides evidence for evolution from a common ancestral gene."Genomics 10:133-142(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B)."Biochem. Biophys. Res. Commun. 163:1498-1504(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of two species of cDNAs for human alpha-N-acetylgalactosaminidase and expression in mammalian cells."Biochem. Biophys. Res. Commun. 170:231-237(1990) [PubMed] [Europe PMC] [Abstract]
  5. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Photolabeling of the alpha-neuraminidase/beta-galactosidase complex from human placenta with a photoreactive neuraminidase inhibitor."Biochem. Biophys. Res. Commun. 173:13-19(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts."J. Lipid Res. 39:1768-1780(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The 1.9 A structure of human alpha-N-acetylgalactosaminidase: the molecular basis of Schindler and Kanzaki diseases."J. Mol. Biol. 393:435-447(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy."J. Clin. Invest. 86:1752-1756(1990) [PubMed] [Europe PMC] [Abstract]
  14. "The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria."J. Clin. Invest. 94:839-845(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype."J. Med. Genet. 33:458-464(1996) [PubMed] [Europe PMC] [Abstract]
  16. "A new case of alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum, with Meniere's syndrome and without mental retardation."Br. J. Dermatol. 144:363-368(2001) [PubMed] [Europe PMC] [Abstract]