≡

Malate Dehydrogenase 1 (MDH1)

[Edit]

MDHA; Malate Dehydrogenase 1,NAD(Soluble); Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase

Malate Dehydrogenase 1 (MDH1)
CCC H673
HGNC 6970
MGI 97051
PubMed 8786100
RGD 3072
UniProt P40925
Wiki MDH1
Malate dehydrogenase (EC 1.1.1.37) (MDH) is an enzyme in the citric acid cycle that catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (this is a reversible reaction). Malate dehydrogenase is not to be confused with malic enzyme, which catalyzes the conversion of malate to pyruvate producing NADPH.
Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH673Hu01 Recombinant Malate Dehydrogenase 1 (MDH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH673Hu01 Polyclonal Antibody to Malate Dehydrogenase 1 (MDH1) WB; IHC; ICC; IP.
MAH673Hu21 Monoclonal Antibody to Malate Dehydrogenase 1 (MDH1) WB; IHC; ICC; IP.
Assay Kits SEH673Hu ELISA Kit for Malate Dehydrogenase 1 (MDH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Malate Dehydrogenase 1 (MDH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Malate Dehydrogenase 1 (MDH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malate Dehydrogenase 1 (MDH1) Polyclonal Antibody Customized Service Offer
Assay Kits SEH673Mu ELISA Kit for Malate Dehydrogenase 1 (MDH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH673Ra01 Recombinant Malate Dehydrogenase 1 (MDH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH673Ra21 Monoclonal Antibody to Malate Dehydrogenase 1 (MDH1) WB; IHC; ICC; IP.
PAH673Ra01 Polyclonal Antibody to Malate Dehydrogenase 1 (MDH1) WB; IHC; ICC; IP.
Assay Kits SEH673Ra ELISA Kit for Malate Dehydrogenase 1 (MDH1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1)."Genomics 32:128-130(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAY-2006) to UniProtKB
  6. "The human myocardial two-dimensional gel protein database: update 1994."Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (MAR-2007) to UniProtKB
  8. "Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes."Ann. Hum. Genet. 52:25-37(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."Biochem. Biophys. Res. Commun. 336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity."J. Lipid Res. 53:1864-1876(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]