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MYC Associated Factor X (MAX)

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BHLHD4; Class D basic helix-loop-helix protein 4

MYC Associated Factor X (MAX)
CCC H676
HGNC 6913
MGI 96921
PubMed 1557420
RGD 621101
UniProt P61244
Wiki MAX
MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Unlike MYC, the steady state level of MAX RNA was not significantly modulated with respect to proliferation or differentiation. Unlike MYC RNA, MAX RNA was relatively stable with a half-life of more than 3 hours, and therefore it did not exhibit the characteristic short half-life of RNAs encoded by most immediate early genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH676Hu01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH676Hu01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; ICC; IHC-P; IHC-F; ELISA.
MAH676Hu21 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
Assay Kits SEH676Hu ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYC Associated Factor X (MAX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYC Associated Factor X (MAX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYC Associated Factor X (MAX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYC Associated Factor X (MAX) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYC Associated Factor X (MAX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYC Associated Factor X (MAX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYC Associated Factor X (MAX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYC Associated Factor X (MAX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYC Associated Factor X (MAX) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYC Associated Factor X (MAX) ELISA Kit Customized Service Offer
  1. "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc."Science 251:1211-1217(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative mRNA forms and open reading frames of the max gene."Oncogene 8:503-507(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation."Science 256:373-377(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."Science 296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
  8. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Max is acetylated by p300 at several nuclear localization residues."Biochem. J. 403:397-407(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain."Nature 363:38-45(1993) [PubMed] [Europe PMC] [Abstract]
  19. "The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control."Structure 5:509-520(1997) [PubMed] [Europe PMC] [Abstract]