Leucine Rich Repeat Kinase 2 (LRRK2)

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AURA17; PARK8; RIPK7; ROCO2; Dardarin ; Parkinson Disease(Autosomal Dominant)8; Leucine-rich repeat serine/threonine-protein kinase 2

Leucine Rich Repeat Kinase 2 (LRRK2)
LRRK2 encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. Mutations in this gene have been associated with Parkinson's disease type 8.Four LRRK2 gene variants found are found in a third of Parkinson’s cases, but infrequent in the general population.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH716Hu01Recombinant Leucine Rich Repeat Kinase 2 (LRRK2)SDS-PAGE; WB; ELISA; IP.
RPH716Hu02Recombinant Leucine Rich Repeat Kinase 2 (LRRK2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH716Hu01Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)WB, ICC, IHC-P, IHC-F, ELISA
PAH716Hu02Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)WB, ICC, IHC-P, IHC-F, ELISA
LAH716Hu71Biotin-Linked Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)IHC;WB;ELISA
Assay KitsSEH716HuELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH716Mu01Recombinant Leucine Rich Repeat Kinase 2 (LRRK2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH716Mu01Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Leucine Rich Repeat Kinase 2 (LRRK2)CLIA Kit Customized Service Offer
n/aELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH716Ra01Recombinant Leucine Rich Repeat Kinase 2 (LRRK2)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAH716Ra21Monoclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)WB, ICC, IHC-P, IHC-F, ELISA
PAH716Ra01Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH716RaELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2)Enzyme-linked immunosorbent assay for Antigen Detection
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  52. "Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe."Hum. Mutat. 33:1087-1098(2012) [PubMed] [Europe PMC] [Abstract]
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