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Interferon Induced Transmembrane Protein 2 (IFITM2)

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DSPA2c; Dispanin subfamily A member 2c; Interferon-inducible protein 1-8D

Interferon Induced Transmembrane Protein 2 (IFITM2)
CCC H829
HGNC 5413
MGI 1933382
PubMed 19544527
RGD 69332
UniProt Q01629
Genomic sequence analysis determined that all 3 IFITMs contain 2 exons, with the interferon-stimulable response elements (ISREs) in the immediately 5-prime flanking sequence of the promoter/enhancer region. Unlike IFITM1, which has an ISRE and 2 CCAAT boxes but lacks a TATA box, IFITM2 and IFITM3 have 2 ISREs and no TATA or CCAAT boxes.
Sequence analysis predicted that the 132-amino acid IFITM2 protein, which is approximately 90% identical to IFITM3, has an N-terminal signal sequence, 3 potential phosphorylation sites, and a C-terminal leucine zipper. Sequence variability is greatest at the C terminus. Immunoblot analysis showed that in response to IFNA, all 3 IFITMs were expressed as 14-kD proteins that could be further resolved by isoelectric focusing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 2 (IFITM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH829Hu ELISA Kit for Interferon Induced Transmembrane Protein 2 (IFITM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH829Mu01 Recombinant Interferon Induced Transmembrane Protein 2 (IFITM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH829Mu ELISA Kit for Interferon Induced Transmembrane Protein 2 (IFITM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 2 (IFITM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 2 (IFITM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Transmembrane Protein 2 (IFITM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Transmembrane Protein 2 (IFITM2) ELISA Kit Customized Service Offer
  1. "Molecular analysis of a human interferon-inducible gene family."Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene."Int. J. Cancer 125:2810-2819(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The small interferon-induced transmembrane genes and proteins."J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The IFITM proteins inhibit HIV-1 infection."J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
  11. ErratumJ. Virol. 85:4043-4043(2011)
  12. "Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."PLoS Pathog. 7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]
  13. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The dispanins: a novel gene family of ancient origin that contains 14 human members."PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]