Huntingtin (HTT)


IT15; HD; Interesting Transcript 15; Huntington disease protein

Huntingtin (HTT)
Huntingtin has no sequence homology with other proteins and is highly expressed in neurons and testes in humans and rodents. Huntingtin upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level but the mechanism by which huntingtin regulated gene expression has not been determined. From immunohistochemistry, electron microscopy, and subcellular fractionation studies of the molecule, it has been found that huntingtin is primarily associated with vesicles and microtubules. These appear to indicate a functional role in cytoskeletal anchoring or transport of mitochondria. The Htt protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin binding protein, to mediate endocytosis, the absorption of materials into a cell.

Organism species: Homo sapiens (Human)

ProteinsRPH922Hu01Recombinant Huntingtin (HTT)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAH922Hu01Polyclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
MAH922Hu21Monoclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
Assay KitsSEH922HuELISA Kit for Huntingtin (HTT)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPH922Mu01Recombinant Huntingtin (HTT)Positive Control; Immunogen; SDS-PAGE; WB.
RPH922Mu02Recombinant Huntingtin (HTT)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAH922Mu01Polyclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
PAH922Mu02Polyclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
Assay KitsSEH922MuELISA Kit for Huntingtin (HTT)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

ProteinsRPH922Ra01Recombinant Huntingtin (HTT)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAH922Ra01Polyclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
MAH922Ra21Monoclonal Antibody to Huntingtin (HTT)WB; IHC; ICC; IP.
Assay KitsSEH922RaELISA Kit for Huntingtin (HTT)Enzyme-linked immunosorbent assay for Antigen Detection.
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