Hepatic fibrosis (Live fibrosis) is the result of an imbalance between production and dissolution of extracellular matrix. Stellate cells, portal myofibroblasts, and bone marrow derived cells converge in a complex interaction with hepatocytes and immune cells to provoke scarring in response to liver injury. Uncovering the specific effects of growth factors on these cells, defining the interaction of different cell population during liver fibrosis and characterizing the genetic determinants of fibrosis progression will enable the discovery of new therapeutic approaches. The outcome of improved understanding of liver fibrosis process, especially the regulation and activation of stellate cells, is reflected in the development of new therapeutic strategies, which are validated in animal models. The most often used animal models for hepatic fibrosis are induced by carbon tetrachloride (CCl4) and bile duct ligation in rats.
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Models | DSI520Mu01 | Mouse Model for Hepatic Fibrosis (HF) | Disease model |
| DSI520Mu02 | Mouse Model for Hepatic Fibrosis (HF) | n/a | |
| Tissues | n/a | Tissue of Hepatic Fibrosis (HF) (If Necessary) | Tissue Customized Service Offer |
| Serums | n/a | Serums of Hepatic Fibrosis (HF) (If Necessary) | Serums Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Models | DSI520Ra01 | Rat Model for Hepatic Fibrosis (HF) | n/a |
| DSI520Ra02 | Rat Model for Hepatic Fibrosis (HF) | n/a | |
| DSI520Ra03 | Rat Model for Hepatic Fibrosis (HF) | n/a | |
| Tissues | n/a | Tissue of Hepatic Fibrosis (HF) (If Necessary) | Tissue Customized Service Offer |
| Serums | n/a | Serums of Hepatic Fibrosis (HF) (If Necessary) | Serums Customized Service Offer |
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Models | DSI520Gu01 | Cavia Model for Hepatic Fibrosis (HF) | n/a |
| DSI520Gu02 | Cavia Model for Hepatic Fibrosis (HF) | n/a | |
| Tissues | n/a | Tissue of Hepatic Fibrosis (HF) (If Necessary) | Tissue Customized Service Offer |
| Serums | n/a | Serums of Hepatic Fibrosis (HF) (If Necessary) | Serums Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Models | DSI520Rb01 | Rabbit Model for Hepatic Fibrosis (HF) | n/a |
| DSI520Rb02 | Rabbit Model for Hepatic Fibrosis (HF) | n/a | |
| Tissues | n/a | Tissue of Hepatic Fibrosis (HF) (If Necessary) | Tissue Customized Service Offer |
| Serums | n/a | Serums of Hepatic Fibrosis (HF) (If Necessary) | Serums Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Models | n/a | Model for Hepatic Fibrosis (HF) | Disease Model Customized Service Offer |
| Tissues | n/a | Tissue of Hepatic Fibrosis (HF) (If Necessary) | Tissue Customized Service Offer |
| Serums | n/a | Serums of Hepatic Fibrosis (HF) (If Necessary) | Serums Customized Service Offer |