Galactokinase 2 (GALK2)

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GK2; N-acetylgalactosamine kinase; GalNAc kinase

Galactokinase 2 (GALK2)
Lee et al. (1992) sought to clone a human galactokinase gene by its ability to substitute for the enzyme in yeast. They used a method for identifying mammalian cDNAs by complementation or other functional activity in yeast. They unexpectedly found that the gene which complemented a galactokinase-deficient strain of Saccharomyces cerevisiae mapped not to chromosome 17 but to chromosome 15, thus calling into question which of the genes, GK1 on 17 or GK2 on 15, is the site of the mutation in the galactokinase deficiency form of galactosemia. The strategy they used might be adopted for cloning various human disease genes affecting intermediary metabolism for which yeast mutants are known. (The mapping to chromosome 15 was done by analysis of genomic DNA from a panel of human-rodent somatic cell hybrids using PCR.)

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Galactokinase 2 (GALK2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Galactokinase 2 (GALK2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Galactokinase 2 (GALK2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Galactokinase 2 (GALK2)CLIA Kit Customized Service Offer
n/aELISA Kit for Galactokinase 2 (GALK2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Galactokinase 2 (GALK2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Galactokinase 2 (GALK2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Galactokinase 2 (GALK2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Galactokinase 2 (GALK2)CLIA Kit Customized Service Offer
n/aELISA Kit for Galactokinase 2 (GALK2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Galactokinase 2 (GALK2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Galactokinase 2 (GALK2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Galactokinase 2 (GALK2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Galactokinase 2 (GALK2)CLIA Kit Customized Service Offer
n/aELISA Kit for Galactokinase 2 (GALK2)ELISA Kit Customized Service Offer
  1. "Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast."Proc. Natl. Acad. Sci. U.S.A. 89:10887-10891(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2."Biochem. Biophys. Res. Commun. 212:687-691(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the GalNAc kinase amino acid sequence."J. Biol. Chem. 271:23653-23656(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The molecular architecture of human N-acetylgalactosamine kinase."J. Biol. Chem. 280:32784-32791(2005) [PubMed] [Europe PMC] [Abstract]