GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2)

[Edit]

ATG8; GATE16; GEF2; FLC3A; General protein transport factor p16; Ganglioside expression factor 2; Golgi-associated ATPase enhancer of 16 kDa; MAP1 light chain 3-related

GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2)
GABARAPL2 contains 117 amino acids and has a calculated molecular mass of 13.7 kD. Like GABARAP, it contains a basic N-terminal tubulin binding domain and a GABA-A receptor binding domain. GABARAPL2 shares 57% identity with GABARAP and 100% amino acid sequence identity with bovine brain GATE16, rat Gabarapl2, and mouse Gabarapl2. Northern blot analysis revealed ubiquitous expression of a 1.35-kb transcript with high levels in heart, brain, testis, prostate, ovary, spleen, and skeletal muscle, and low levels in lung, thymus, and small intestine. GABARAPL2 had activity as a soluble transport factor, it interacted with N-ethylmaleimide-sensitive factor (NSF) and stimulated its ATPase activity, and interacted with the Golgi v-SNARE (GOS28) in an NSF-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ288Hu01 Recombinant GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ288Hu01 Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) WB; IHC; ICC; IP.
MAJ288Hu21 Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) WB; IHC; ICC; IP.
Assay Kits SEJ288Hu ELISA Kit for GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) ELISA Kit Customized Service Offer
  1. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."Genomics 74:408-413(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
  7. "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."Biochem. Biophys. Res. Commun. 300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
  8. "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."J. Cell Sci. 117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
  9. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The TP53INP2 protein is required for autophagy in mammalian cells."Mol. Biol. Cell 20:870-881(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."EMBO J. 29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Network organization of the human autophagy system."Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
  18. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
  19. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."Mol. Cell. Biol. 32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens."Mol. Cell. Proteomics 11:M111.014035.1-M111.014035.17(2012) [PubMed] [Europe PMC] [Abstract]
  22. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."J. Biol. Chem. 288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]