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Coactosin Like Protein 1 (COTL1)

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CLP

Coactosin Like Protein 1 (COTL1)
CCC J353
HGNC 18304
MGI 1919292
PubMed 19307756
RGD 1305498
UniProt Q14019
Wiki COTL1
COTL1 encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.the 2.0-kb CLP transcript is expressed predominantly in placenta, lung, and kidney, with lower levels in brain, liver, and pancreas. In heart, they detected an additional band of 1.4 kb. In immune tissues, highest expression of CLP was in peripheral blood leukocytes, with lower levels in spleen and lymph node.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ353Hu01 Recombinant Coactosin Like Protein 1 (COTL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ353Hu01 Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC/IF
MAJ353Hu21 Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) WB; IHC; ICC; IP.
Assay Kits SEJ353Hu ELISA Kit for Coactosin Like Protein 1 (COTL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coactosin Like Protein 1 (COTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coactosin Like Protein 1 (COTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coactosin Like Protein 1 (COTL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coactosin Like Protein 1 (COTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coactosin Like Protein 1 (COTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coactosin Like Protein 1 (COTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coactosin Like Protein 1 (COTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coactosin Like Protein 1 (COTL1) ELISA Kit Customized Service Offer
  1. "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome."Nat. Genet. 17:154-163(1997) [PubMed] [Europe PMC] [Abstract]
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  5. , Submitted (MAR-2007) to UniProtKB
  6. "Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75."Biochem. J. 359:255-263(2001) [PubMed] [Europe PMC] [Abstract]
  7. "5-lipoxygenase interacts with coactosin-like protein."J. Biol. Chem. 276:16520-16527(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."Biochem. J. 425:265-274(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "NMR structure of human coactosin-like protein."J. Biomol. NMR 30:353-356(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human coactosin-like protein at 1.9 A resolution."Protein Sci. 13:2845-2851(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Binding model of human coactosin-like protein with filament actin revealed by mutagenesis."Biochim. Biophys. Acta 1764:1688-1700(2006) [PubMed] [Europe PMC] [Abstract]