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Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3)

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NIP3

Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3)
CCC J545
HGNC 1084
MGI 109326
PubMed 22292033
RGD 1565371
UniProt Q12983
Wiki BNIP3
BNIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function.
The NIP3 protein has 194 amino acids and contains a putative membrane-spanning hydrophobic domain. Although the NIP3 cDNA sequence is highly homologous to a rat cDNA that encodes the rat brain calbindin-D protein, the authors determined that the NIP3 protein is encoded by a unique mRNA in human cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ545Hu01 Recombinant Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ545Hu ELISA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ545Ra01 Recombinant Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ545Ra01 Polyclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) WB; IHC; ICC; IP.
MAJ545Ra21 Monoclonal Antibody to Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) WB; IHC; ICC; IP.
Assay Kits SEJ545Ra ELISA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCJ545Ra CLIA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Chemiluminescent immunoassay for Antigen Detection.
  1. "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins."Cell 79:341-351(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis."J. Exp. Med. 186:1975-1983(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region."Cell Death Differ. 6:314-325(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines."Biochim. Biophys. Acta 1780:873-880(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3."Cell Res. 20:314-331(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria."PLoS ONE 7:E30767-E30767(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]