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Aconitase 1 (ACO1)

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IREB1; IRP1; IREBP; Iron regulatory protein 1; Iron-responsive element-binding protein 1; Cytoplasmic aconitate hydratase; Citrate hydro-lyase; Ferritin repressor protein

Aconitase 1 (ACO1)
CCC J683
HGNC 117
MGI 87879
PubMed 10631981
RGD 2019
UniProt P21399
Aconitase 1 is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. The cytoplasmic IREBP interacts with the IREs of these mRNAs. The iron status of the cell determines the ability of IREBP to bind to an IRE through reversible oxidation-reduction of sulfhydryl groups that are critical for the high-affinity RNA-protein interaction. Thus, IREBP plays a central role in cellular iron homeostasis by regulating ferritin mRNA translation and TFRC mRNA stability

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ683Hu01 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ683Hu02 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ683Hu03 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ683Hu04 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ683Hu01 Polyclonal Antibody to Aconitase 1 (ACO1) WB; ICC; IHC-P; IHC-F; ELISA.
PAJ683Hu03 Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
PAJ683Hu04 Polyclonal Antibody to Aconitase 1 (ACO1) WB; ICC; IHC-P; IHC-F; ELISA.
PAJ683Hu02 Polyclonal Antibody to Aconitase 1 (ACO1) WB; ICC; IHC-P; IHC-F; ELISA.
LAJ683Hu71 Biotin-Linked Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC.
Assay Kits SEJ683Hu ELISA Kit for Aconitase 1 (ACO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ683Mu01 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ683Mu02 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ683Mu03 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ683Mu01 Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
LAJ683Mu71 Biotin-Linked Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC.
PAJ683Mu02 Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
PAJ683Mu03 Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
Assay Kits SEJ683Mu ELISA Kit for Aconitase 1 (ACO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ683Ra01 Recombinant Aconitase 1 (ACO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ683Ra21 Monoclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
PAJ683Ra01 Polyclonal Antibody to Aconitase 1 (ACO1) WB; IHC; ICC; IP.
Assay Kits SEJ683Ra ELISA Kit for Aconitase 1 (ACO1) Enzyme-linked immunosorbent assay for Antigen Detection.
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