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Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb)

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PI3K; PI3Kbeta; PIK3C1; p110-BETA; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb)
CCC J829
HGNC 8976
MGI 1922019
PubMed 18755892
RGD 620917
UniProt P42338
Wiki PIK3CB
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit.
The predicted 1,070-amino acid protein, called p110-beta by them, is 42% identical to that of bovine p110. Northern blot analysis revealed that the major 4.8-kb p110-beta transcript was expressed in several human and rodent cell lines, as well as in all mouse tissues tested. Minor larger transcripts were detected in some tissues and cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ829Hu01 Recombinant Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ829Hu02 Recombinant Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ829Hu03 Recombinant Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ829Hu01 Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) WB; IHC; ICC; IP.
PAJ829Hu02 Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) WB; IHC; IF
PAJ829Hu03 Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) WB; IHC; ICC; IP.
LAJ829Hu71 Biotin-Linked Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) WB; IHC; ICC.
Assay Kits SEJ829Hu ELISA Kit for Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ829Mu01 Recombinant Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ829Ra ELISA Kit for Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85."Mol. Cell. Biol. 13:7677-7688(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes."Diabetes 49:1740-1743(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma."J. Biol. Chem. 278:11536-11545(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis."Nature 454:776-779(2008) [PubMed] [Europe PMC] [Abstract]
  6. "PTEN-deficient cancers depend on PIK3CB."Proc. Natl. Acad. Sci. U.S.A. 105:13057-13062(2008) [PubMed] [Europe PMC] [Abstract]
  7. "p85 Associates with unphosphorylated PTEN and the PTEN-associated complex."Mol. Cell. Biol. 29:5377-5388(2009) [PubMed] [Europe PMC] [Abstract]
  8. "A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase."Proc. Natl. Acad. Sci. U.S.A. 107:19897-19902(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival."Mol. Cell. Biol. 31:2122-2133(2011) [PubMed] [Europe PMC] [Abstract]
  11. "A beta version of life: p110beta takes center stage."Oncotarget 1:729-733(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions."Adv. Enzyme Regul. 51:106-116(2011) [PubMed] [Europe PMC] [Abstract]