Caspase Recruitment Domain Family, Member 14 (CARD14)

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CARMA2; BIMP2; CARD-containing MAGUK protein 2

Caspase Recruitment Domain Family, Member 14 (CARD14)
CARD14 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Caspase Recruitment Domain Family, Member 14 (CARD14)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Caspase Recruitment Domain Family, Member 14 (CARD14)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Caspase Recruitment Domain Family, Member 14 (CARD14)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Caspase Recruitment Domain Family, Member 14 (CARD14)CLIA Kit Customized Service Offer
n/aELISA Kit for Caspase Recruitment Domain Family, Member 14 (CARD14)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Caspase Recruitment Domain Family, Member 14 (CARD14)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Caspase Recruitment Domain Family, Member 14 (CARD14)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Caspase Recruitment Domain Family, Member 14 (CARD14)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Caspase Recruitment Domain Family, Member 14 (CARD14)CLIA Kit Customized Service Offer
n/aELISA Kit for Caspase Recruitment Domain Family, Member 14 (CARD14)ELISA Kit Customized Service Offer
  1. "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB."J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract]
  3. ErratumFEBS Lett. 505:198-198(2001)
  4. "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."J. Cell. Physiol. 226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "PSORS2 is due to mutations in CARD14."Am. J. Hum. Genet. 90:784-795(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Familial pityriasis rubra pilaris is caused by mutations in CARD14."Am. J. Hum. Genet. 91:163-170(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis." Am. J. Hum. Genet. 90:796-808(2012) [PubMed] [Europe PMC] [Abstract]