Mitochondrial Carrier Homolog 2 (MTCH2)

The mouse and human MIMP proteins contain 303 amino acids and share 93% identity. Mimp has characteristics of a mitochondrial carrier protein, including 6 transmembrane domains, weak tandem repeats, and an energy transfer signature motif.

Northern blot and RNA dot-blot analyses of mouse tissues revealed ubiquitous expression. Expression was highest in testis and brain and moderate in smooth muscle, thyroid, submaxillary gland, and epididymis. MIMP was also expressed in a number of human epithelial cell lines. Transfection of epitope-tagged Mimp followed by immunohistochemical analysis and subcellular fractionation experiments confirmed that Mimp is a mitochondrial protein.