Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)

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HRT3; bHLHb33; Hairy-related transcription factor 3; Hairy/Enhancer Of Split Related With YRPW Motif Protein 3; Class B basic helix-loop-helix protein 33

Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)
HEYL encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.The deduced 328-amino acid protein contains the basic helix-loop-helix and orange domains conserved in HEY proteins, but it lacks the YRPW motif found in HEY1 and HEY2. HEYL shares 78% amino acid identity with the mouse protein, with most divergence in the C-terminal domain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)CLIA Kit Customized Service Offer
n/aELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)CLIA Kit Customized Service Offer
n/aELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)CLIA Kit Customized Service Offer
n/aELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Like Protein (HEYL)ELISA Kit Customized Service Offer
  1. "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."Biochem. Biophys. Res. Commun. 275:652-660(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]