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Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7)

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CD319; CRACC; 19A; CS1; CD2-like receptor-activating cytotoxic cells; Membrane protein FOAP-12

Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7)
CCC K384
HGNC 21394
MGI 1922595
PubMed 23695528
RGD 1560190
UniProt Q9NQ25
Wiki SLAMF7
Sequence analysis predicted that the 335-amino acid transmembrane protein has a 225-residue extracellular domain, which has 7 putative N-linked glycosylation sites, and an 85-amino acid cytoplasmic domain, which contains 2 of the consensus tyrosine motifs and a third C-terminal tyrosine motif that has phe instead of thr.
Functional analysis indicated that CRACC mediates lysis that is in addition to that mediated by NKP46 or CD16. Further analysis determined that, unlike CD244, cytotoxicity mediated by CRACC or NKP46 is SAP-independent and that CRACC triggers ERK activation. Immunoblot analysis showed that CRACC is tyrosine phosphorylated in activated NK cells and is associated with 19- and 39-kD proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK384Hu01 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Positive Control; Immunogen; SDS-PAGE; WB.
RPK384Hu02 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK384Hu01 Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) WB; IHC; ICC; IP.
MAK384Hu21 Monoclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) WB; IHC; ICC; IP.
Assay Kits SEK384Hu ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) ELISA Kit Customized Service Offer
  1. "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily."Immunogenetics 52:302-307(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family."J. Immunol. 167:5517-5521(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion."Biochem. J. 361:431-436(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs."Eur. J. Immunol. 34:2791-2799(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors."Immunogenetics 54:394-402(2002) [PubMed] [Europe PMC] [Abstract]