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Gastrokine 3 (GKN3)

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Gastrokine 3 (GKN3)
CCC K528
MGI 1916138
PubMed 20138039
UniProt Q9D0T7
A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. Gkn3 encodes a secreted protein that is co-expressed with trefoil factor (Tff)2 in the distal stomach and discriminates a Griffinia simplicifolia lectin (GS)-II-positive mucus neck cell (MNC) subpopulation in the proximal stomach. In humans, widespread homozygosity for a premature stop codon polymorphism, W59X, has likely rendered GKN3 non-functional. Mouse Gkn3 expression is strongly up-regulated in (Tff2-deficient) gastric atrophy, a pre-cancerous state that is typically associated with Helicobacter pylori and marks a non-proliferative, GS-II positive lineage with features of spasmolytic polypeptide-expressing metaplasia (SPEM). Gkn3 overexpression inhibits proliferation in gastric epithelial cell lines, independently of incubation with recombinant human TFF2 or apoptosis.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK528Mu01 Recombinant Gastrokine 3 (GKN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK528Mu01 Polyclonal Antibody to Gastrokine 3 (GKN3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gastrokine 3 (GKN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gastrokine 3 (GKN3) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK528Po01 Recombinant Gastrokine 3 (GKN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK528Po01 Polyclonal Antibody to Gastrokine 3 (GKN3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gastrokine 3 (GKN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gastrokine 3 (GKN3) ELISA Kit Customized Service Offer
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