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Angiogenin 3 (ANG3)

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EF-5; Angl; Angiogenin-Related Protein 2

Angiogenin 3 (ANG3)
CCC K537
MGI 1201793
PubMed 23170778
UniProt P97802
Mouse angiogenin-3 has been identified by virtue of its transcriptional activation in NIH 3T3 fibroblasts coincident with transformation by the chimeric leukemia oncogene, E2a-Pbx1. The protein has been identified independently as EF-5, a gene expressed in NIH 3T3 fibroblast following transformation with the E2a-Pbx1 oncoprotein. Other names for angiogenin-3 in databanks are Angrp2 and Angl, and Rnase5c .
Angiogenin-3 is a ribonuclease. Its activity and specificity towards tRNA and dinucleotide substrates differs from those of mouse angiogenin or of mouse angiogenin-related protein, a non-angiogenic factor. Mouse angiogenin-3 induces angiogenesis in both the Chicken chorioallantoic membrane assay and the rat cremaster muscle.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiogenin 3 (ANG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiogenin 3 (ANG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiogenin 3 (ANG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiogenin 3 (ANG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiogenin 3 (ANG3) ELISA Kit Customized Service Offer
  1. "E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts."Mol. Cell. Biol. 17:1503-1512(1997) [PubMed] [Europe PMC] [Abstract]
  2. "High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins."Protein Expr. Purif. 22:307-317(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues."FEBS J. 280:302-318(2013) [PubMed] [Europe PMC] [Abstract]