PTEN Induced Putative Kinase 1 (PINK1)

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BRPK; PARK6; Parkinson Disease(Autosomal Recessive)6; Serine/threonine-protein kinase PINK1, mitochondrial

PTEN Induced Putative Kinase 1 (PINK1)
PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
The protein shares 43% and 31% sequence identity with Drosophila CG4523 and C. elegans EEED8.9, respectively. Northern blot analysis detected ubiquitous expression of a 2.7-kb transcript, with highest expression in heart, skeletal muscle, and testis. RT-PCR analysis showed that expression of PINK1 was decreased in ovarian tumors compared with corresponding normal tissues.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPL057Hu01Recombinant PTEN Induced Putative Kinase 1 (PINK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAL057Hu01Polyclonal Antibody to PTEN Induced Putative Kinase 1 (PINK1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for PTEN Induced Putative Kinase 1 (PINK1)CLIA Kit Customized Service Offer
n/aELISA Kit for PTEN Induced Putative Kinase 1 (PINK1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPL057Mu01Recombinant PTEN Induced Putative Kinase 1 (PINK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAL057Mu01Polyclonal Antibody to PTEN Induced Putative Kinase 1 (PINK1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for PTEN Induced Putative Kinase 1 (PINK1)CLIA Kit Customized Service Offer
n/aELISA Kit for PTEN Induced Putative Kinase 1 (PINK1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PTEN Induced Putative Kinase 1 (PINK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PTEN Induced Putative Kinase 1 (PINK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PTEN Induced Putative Kinase 1 (PINK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PTEN Induced Putative Kinase 1 (PINK1)CLIA Kit Customized Service Offer
n/aELISA Kit for PTEN Induced Putative Kinase 1 (PINK1)ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Lung.
  5. "The kinase domain of mitochondrial PINK1 faces the cytoplasm."Proc. Natl. Acad. Sci. U.S.A. 105:12022-12027(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation."J. Clin. Invest. 119:650-660(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations."Autophagy 6:871-878(2010) [PubMed] [Europe PMC] [Abstract]
  8. "PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy."J. Cell Biol. 189:211-221(2010) [PubMed] [Europe PMC] [Abstract]
  9. "PINK1-dependent recruitment of Parkin to mitochondria in mitophagy."Proc. Natl. Acad. Sci. U.S.A. 107:378-383(2010) [PubMed] [Europe PMC] [Abstract]
  10. "PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria."Nat. Commun. 3:1016-1016(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation."J. Biol. Chem. 288:22019-22032(2013) [PubMed] [Europe PMC] [Abstract]
  12. "The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy."Nat. Neurosci. 16:1257-1265(2013) [PubMed] [Europe PMC] [Abstract]
  13. "PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria."Science 340:471-475(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65."Biochem. J. 460:127-139(2014) [PubMed] [Europe PMC] [Abstract]
  15. "PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity."J. Cell Biol. 205:143-153(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Ubiquitin is phosphorylated by PINK1 to activate parkin."Nature 510:162-166(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy."Nature 510:370-375(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis."EMBO J. 34:307-325(2015) [PubMed] [Europe PMC] [Abstract]
  19. "PINK1 mutations are associated with sporadic early-onset parkinsonism."Ann. Neurol. 56:336-341(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Novel PINK1 mutations in early-onset parkinsonism."Ann. Neurol. 56:424-427(2004) [PubMed] [Europe PMC] [Abstract]
  21. ErratumAnn. Neurol. 56:603-603(2004)
  22. "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." Arch. Neurol. 61:1898-1904(2004) [PubMed] [Europe PMC] [Abstract]
  23. "PINK1 (PARK6) associated Parkinson disease in Ireland."Neurology 63:1486-1488(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Hereditary early-onset Parkinson's disease caused by mutations in PINK1." Science 304:1158-1160(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Analysis of PINK1 in Asian patients with familial parkinsonism."Clin. Genet. 68:468-470(2005) [PubMed] [Europe PMC] [Abstract]
  26. "PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism."Eur. J. Hum. Genet. 13:1086-1093(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism."Hum. Mol. Genet. 14:3477-3492(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism."Neurology 64:1955-1957(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes." Neurology 65:87-95(2005) [PubMed] [Europe PMC] [Abstract]
  30. "A heterozygous effect for PINK1 mutations in Parkinson's disease?"Ann. Neurol. 60:414-419(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1."Arch. Neurol. 63:1257-1261(2006) [PubMed] [Europe PMC] [Abstract]
  32. "T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease."Arch. Neurol. 63:1483-1485(2006) [PubMed] [Europe PMC] [Abstract]
  33. "Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa."Brain 129:686-694(2006) [PubMed] [Europe PMC] [Abstract]
  34. "Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease."Hum. Mol. Genet. 15:1816-1825(2006) [PubMed] [Europe PMC] [Abstract]
  35. "PINK1 mutations in sporadic early-onset Parkinson's disease."Mov. Disord. 21:789-793(2006) [PubMed] [Europe PMC] [Abstract]
  36. "Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan."Neurosci. Lett. 394:33-36(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  38. "PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum." Hum. Mutat. 29:565-565(2008) [PubMed] [Europe PMC] [Abstract]
  39. "Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation."J. Neurol. 255:643-648(2008) [PubMed] [Europe PMC] [Abstract]
  40. "Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease." Mov. Disord. 27:1522-1529(2012) [PubMed] [Europe PMC] [Abstract]