Parkinson Disease Protein 7 (PARK7)


DJ1; Autosomal Recessive,Early Onset

Parkinson Disease Protein 7 (PARK7)
PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.
Northern blot analysis revealed that DJ1 is ubiquitously expressed as a 1.0-kb transcript. Western blot analysis and immunofluorescence showed that the DJ1 protein is present in both nuclei and cytoplasm of HeLa cells.A search of the GenBank protein database revealed that DJ1 has approximately 40% identity to the 198-amino acid protein product of the E. coli thiazole monophosphate biosynthesis (ThiJ) gene. A homolog also exists in the nematode C. elegans.

Organism species: Homo sapiens (Human)

ProteinsRPL059Hu01Recombinant Parkinson Disease Protein 7 (PARK7)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAL059Hu01Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)WB, ICC, IHC-P, IHC-F, ELISA
LAL059Hu71Biotin-Linked Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)IHC;WB;ELISA
LAL059Hu81FITC-Linked Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)IHC;ICC;IF;WB
MAL059Hu21Monoclonal Antibody to Parkinson Disease Protein 7 (PARK7)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEL059HuELISA Kit for Parkinson Disease Protein 7 (PARK7)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

ProteinsRPL059Mu01Recombinant Parkinson Disease Protein 7 (PARK7)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAL059Mu01Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)WB, ICC, IHC-P, IHC-F, ELISA
LAL059Mu71Biotin-Linked Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)IHC;WB;ELISA
LAL059Mu81FITC-Linked Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)IHC;ICC;IF;WB
Assay Kitsn/aCLIA Kit for Parkinson Disease Protein 7 (PARK7)CLIA Kit Customized Service Offer
n/aELISA Kit for Parkinson Disease Protein 7 (PARK7)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

ProteinsRPL059Ra01Recombinant Parkinson Disease Protein 7 (PARK7)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAL059Ra01Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)WB, ICC, IHC-P, IHC-F, ELISA
LAL059Ra71Biotin-Linked Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7)IHC;WB;ELISA
MAL059Ra21Monoclonal Antibody to Parkinson Disease Protein 7 (PARK7)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Parkinson Disease Protein 7 (PARK7)CLIA Kit Customized Service Offer
n/aELISA Kit for Parkinson Disease Protein 7 (PARK7)ELISA Kit Customized Service Offer
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  6. , Submitted (DEC-2008) to UniProtKB
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  23. "Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage."Hum. Mol. Genet. 19:2395-2408(2010) [PubMed] [Europe PMC] [Abstract]
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  27. "DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes."Hum. Mol. Genet. 22:4805-4817(2013) [PubMed] [Europe PMC] [Abstract]
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  29. "Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine and lysine residues."J. Biol. Chem. 290:1885-1897(2015) [PubMed] [Europe PMC] [Abstract]
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  32. "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease."J. Biol. Chem. 278:31372-31379(2003) [PubMed] [Europe PMC] [Abstract]
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  34. "Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain."J. Biol. Chem. 278:44552-44559(2003) [PubMed] [Europe PMC] [Abstract]
  35. "The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease."Proc. Natl. Acad. Sci. U.S.A. 100:9256-9261(2003) [PubMed] [Europe PMC] [Abstract]
  36. "The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization."Proc. Natl. Acad. Sci. U.S.A. 101:9103-9108(2004) [PubMed] [Europe PMC] [Abstract]
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  38. "Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism."Science 299:256-259(2003) [PubMed] [Europe PMC] [Abstract]
  39. "The R98Q variation in DJ-1 represents a rare polymorphism."Ann. Neurol. 55:145-146(2004) [PubMed] [Europe PMC] [Abstract]
  40. "Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)."Hum. Mutat. 24:321-329(2004) [PubMed] [Europe PMC] [Abstract]
  41. "Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1."J. Biol. Chem. 279:6943-6951(2004) [PubMed] [Europe PMC] [Abstract]
  42. "Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations."Mov. Disord. 19:796-800(2004) [PubMed] [Europe PMC] [Abstract]
  43. "DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease."Neurology 62:389-394(2004) [PubMed] [Europe PMC] [Abstract]
  44. "DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex."Ann. Neurol. 58:803-807(2005) [PubMed] [Europe PMC] [Abstract]
  45. "Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease."Hum. Mol. Genet. 15:1816-1825(2006) [PubMed] [Europe PMC] [Abstract]
  46. "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6."J. Cell Biol. 178:1025-1038(2007) [PubMed] [Europe PMC] [Abstract]
  47. "Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1."PLoS ONE 5:E9367-E9367(2010) [PubMed] [Europe PMC] [Abstract]