Parkinson Disease Protein 2 (PARK2)


AR-JP; LPRS2; PDJ; PRKN; Parkin; Autosomal Recessive,Juvenile; E3 ubiquitin-protein ligase parkin

Parkinson Disease Protein 2 (PARK2)
Parkin is a proteinencoded by the PARK2 gene.The precise function of this protein is unknown; however, the protein is a component of a multiprotein E3 ubiquitin ligase complex which in turn is part of the ubiquitin-proteasome system that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause a familial form of Parkinson's disease known as autosomal recessive juvenile Parkinson disease.
PARK2 is the parkin gene that may cause a form of autosomal recessive juvenile Parkinson disease due to a mutation in the parkin protein. This form of genetic mutation may be one of the most common known genetic causes of early-onset Parkinson disease.

Organism species: Homo sapiens (Human)

Proteins RPL060Hu01 Recombinant Parkinson Disease Protein 2 (PARK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL060Hu21 Monoclonal Antibody to Parkinson Disease Protein 2 (PARK2) WB; IHC; ICC; IP.
PAL060Hu01 Polyclonal Antibody to Parkinson Disease Protein 2 (PARK2) WB; IHC; ICC; IP.
Assay Kits SEL060Hu ELISA Kit for Parkinson Disease Protein 2 (PARK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins n/a Recombinant Parkinson Disease Protein 2 (PARK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parkinson Disease Protein 2 (PARK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parkinson Disease Protein 2 (PARK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parkinson Disease Protein 2 (PARK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parkinson Disease Protein 2 (PARK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

Proteins n/a Recombinant Parkinson Disease Protein 2 (PARK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parkinson Disease Protein 2 (PARK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parkinson Disease Protein 2 (PARK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parkinson Disease Protein 2 (PARK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parkinson Disease Protein 2 (PARK2) ELISA Kit Customized Service Offer
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  22. "Parkin interacts with the proteasome subunit alpha4."FEBS Lett. 579:3913-3919(2005) [PubMed] [Europe PMC] [Abstract]
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  41. "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."Nature 504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
  42. "PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria."Science 340:471-475(2013) [PubMed] [Europe PMC] [Abstract]
  43. "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65."Biochem. J. 460:127-139(2014) [PubMed] [Europe PMC] [Abstract]
  44. "PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity."J. Cell Biol. 205:143-153(2014) [PubMed] [Europe PMC] [Abstract]
  45. "Ubiquitin is phosphorylated by PINK1 to activate parkin."Nature 510:162-166(2014) [PubMed] [Europe PMC] [Abstract]
  46. "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy."Nature 510:370-375(2014) [PubMed] [Europe PMC] [Abstract]
  47. "Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis."EMBO J. 34:307-325(2015) [PubMed] [Europe PMC] [Abstract]
  48. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]
  49. "Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain."EMBO Rep. 4:301-306(2003) [PubMed] [Europe PMC] [Abstract]
  50. "Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease."Proc. Natl. Acad. Sci. U.S.A. 104:3095-3100(2007) [PubMed] [Europe PMC] [Abstract]
  51. "Structure of the human Parkin ligase domain in an autoinhibited state."EMBO J. 32:2099-2112(2013) [PubMed] [Europe PMC] [Abstract]
  52. "Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases."Nat. Commun. 4:1982-1982(2013) [PubMed] [Europe PMC] [Abstract]
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  54. "Point mutations (Thr240Arg and Gln311Stop) in the Parkin gene."Biochem. Biophys. Res. Commun. 249:754-758(1998) [PubMed] [Europe PMC] [Abstract]
  55. ErratumBiochem. Biophys. Res. Commun. 251:666-666(1998)
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  65. ErratumAm. J. Med. Genet. 114:992-992(2002)
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  69. "Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism."J. Neurol. Neurosurg. Psych. 73:582-584(2002) [PubMed] [Europe PMC] [Abstract]
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  73. "Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease."Neurology 60:796-801(2003) [PubMed] [Europe PMC] [Abstract]
  74. "Parkin mutations are rare in patients with young-onset parkinsonism in a US population."Parkinsonism Relat. Disord. 9:309-312(2003) [PubMed] [Europe PMC] [Abstract]
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  76. "PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy."J. Cell Biol. 189:211-221(2010) [PubMed] [Europe PMC] [Abstract]
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