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Notch Homolog 2 (NOTCH2)

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AGS2; hN2; Neurogenic locus notch homolog protein 2

Notch Homolog 2 (NOTCH2)
CCC L148
HGNC 7882
MGI 97364
PubMed 22018469
RGD 3188
UniProt Q04721
Wiki NOTCH2
NOTCH2 encodes a member of the Notch family. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL148Hu01 Recombinant Notch Homolog 2 (NOTCH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL148Hu21 Monoclonal Antibody to Notch Homolog 2 (NOTCH2) WB; IHC; ICC; IP.
PAL148Hu01 Polyclonal Antibody to Notch Homolog 2 (NOTCH2) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEL148Hu ELISA Kit for Notch Homolog 2 (NOTCH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL148Mu01 Recombinant Notch Homolog 2 (NOTCH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Notch Homolog 2 (NOTCH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Notch Homolog 2 (NOTCH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Notch Homolog 2 (NOTCH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notch Homolog 2 (NOTCH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL148Ra01 Recombinant Notch Homolog 2 (NOTCH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Notch Homolog 2 (NOTCH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Notch Homolog 2 (NOTCH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Notch Homolog 2 (NOTCH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notch Homolog 2 (NOTCH2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins."Nat. Genet. 2:119-127(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane."Cell 90:281-291(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Human ligands of the Notch receptor."Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
  5. "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."Nat. Genet. 26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."J. Biol. Chem. 282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways."Proc. Natl. Acad. Sci. U.S.A. 105:3368-3373(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis."Nat. Genet. 43:306-308(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss."Nat. Genet. 43:303-305(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for autoinhibition of Notch."Nat. Struct. Mol. Biol. 14:295-300(2007) [PubMed] [Europe PMC] [Abstract]
  16. "NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway."Am. J. Hum. Genet. 79:169-173(2006) [PubMed] [Europe PMC] [Abstract]