POU Domain Class 4 Transcription Factor 2 (POU4F2)

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BRN3.2; BRN3B; Brn-3b; Brain-specific homeobox/POU domain protein 3B

POU Domain Class 4 Transcription Factor 2 (POU4F2)
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.The BRN3B gene encodes a 410-amino acid polypeptide that contains several identifiable motifs, including a glycine/serine-rich domain, a histidine-rich domain, and a POU domain. RNA slot blots showed that BRN3B is expressed predominantly in the retina. Immunocytochemistry indicated that the protein is present in the nuclei of a subset of retinal ganglion cells, consistent with its role as a transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 4 Transcription Factor 2 (POU4F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 4 Transcription Factor 2 (POU4F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 4 Transcription Factor 2 (POU4F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 4 Transcription Factor 2 (POU4F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 4 Transcription Factor 2 (POU4F2)ELISA Kit Customized Service Offer
  1. "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells."Neuron 11:689-701(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain."Nucleic Acids Res. 21:2946-2946(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells."Proc. Natl. Acad. Sci. U.S.A. 90:10260-10264(1993) [PubMed] [Europe PMC] [Abstract]