Egl Nine Homolog 1 (EGLN1)


ECYT3; HIFPH2; PHD2; C1orf12; SM20; ZMYND6; HIF Prolyl Hydroxylase 2; Prolyl hydroxylase domain-containing protein 2; Hypoxia-inducible factor prolyl hydroxylase 2

Egl Nine Homolog 1 (EGLN1)
EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. The genes encoding these proteins were cloned and termed PHD1, PHD2, and PHD3 by the authors. Direct modulation of recombinant enzyme activity by graded hypoxia, iron chelation, and cobaltous ions mirrored the characteristics of HIF induction in vivo, fulfilling requirements for these enzymes being oxygen sensors that regulate HIF.

Organism species: Homo sapiens (Human)

ProteinsRPL644Hu01Recombinant Egl Nine Homolog 1 (EGLN1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesMAL644Hu21Monoclonal Antibody to Egl Nine Homolog 1 (EGLN1)WB; IHC; ICC; IP.
PAL644Hu01Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1)WB; IHC; ICC; IP.
Assay KitsSEL644HuELISA Kit for Egl Nine Homolog 1 (EGLN1)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPL644Mu01Recombinant Egl Nine Homolog 1 (EGLN1)Positive Control; Immunogen; SDS-PAGE; WB.
RPL644Mu02Recombinant Egl Nine Homolog 1 (EGLN1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAL644Mu01Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1)WB; IHC; ICC; IP.
PAL644Mu02Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1)WB; IHC; ICC; IP.
Assay KitsSEL644MuELISA Kit for Egl Nine Homolog 1 (EGLN1)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

Proteinsn/aRecombinant Egl Nine Homolog 1 (EGLN1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Egl Nine Homolog 1 (EGLN1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Egl Nine Homolog 1 (EGLN1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Egl Nine Homolog 1 (EGLN1)CLIA Kit Customized Service Offer
n/aELISA Kit for Egl Nine Homolog 1 (EGLN1)ELISA Kit Customized Service Offer
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