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Wingless Type MMTV Integration Site Family, Member 4 (WNT4)

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Wingless Type MMTV Integration Site Family, Member 4 (WNT4)
CCC L817
HGNC 12783
MGI 98957
PubMed 17976036
RGD 621348
UniProt P56705
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT4 is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL817Hu01 Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL817Hu21 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC
PAL817Hu01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC; ICC; IP.
MAL817Hu22 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC; ICC; IP.
MAL817Hu23 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC; ICC; IP.
Assay Kits SEL817Hu ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Polyclonal Antibody Customized Service Offer
Assay Kits SEL817Mu ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL817Ra01 Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL817Ra01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC; ICC; IP.
MAL817Ra21 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4) WB; IHC; ICC; IP.
Assay Kits SEL817Ra ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCL817Ra CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Chemiluminescent immunoassay for Antigen Detection.
  1. "Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans."Am. J. Hum. Genet. 68:1102-1109(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
  7. "A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman."N. Engl. J. Med. 351:792-798(2004) [PubMed] [Europe PMC] [Abstract]
  8. "WNT4 deficiency-a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report."Hum. Reprod. 22:224-229(2007) [PubMed] [Europe PMC] [Abstract]
  9. "SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4."Am. J. Hum. Genet. 82:39-47(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study."J. Clin. Endocrinol. Metab. 93:895-900(2008) [PubMed] [Europe PMC] [Abstract]